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Ntopng doker5/7/2023 The papers forming this PLOS Special Collection, Post pandemic: How will COVID-19 transform global health? were conceived as a road-map to catalyse a global health research and policy agenda necessary to end the pandemic, shape the post-COVID-19 global health recovery and lay the foundations for a more resilient global landscape to achieve the goals of sustainable development. For now, a high priority in ending the pandemic, as well as accelerating the post-COVID-19 recovery, must be determining what an effective global response to COVID-19 entails. For decades to come, we will undoubtedly continue critical reflection on why some countries, including less-resourced countries, have been able to respond more effectively to COVID-19, while some well-resourced countries have struggled. To achieve a new normal requires a coordinated, coherent and cohesive response that is effective globally for sustainability. The pandemic has also highlighted our interdependence. Within and between countries we have witnessed how already vulnerable and marginalized populations bear a disproportionate burden of infection, with reversal of the development gains made to date. No country or region has been spared the crisis has laid bare stark weaknesses in almost every health care system. In the United States (US) alone, the pandemic’s total cost is estimated at more than US$16 trillion, or approximately 90% of the country’s annual gross domestic product. The economic and social impact is formidable and growing. The impact on other pandemics and health challenges is masked by the continued dominance of COVID-19 on our lives. To date, more than 100 million people have been infected and over 2.1 million died likely the tip of the iceberg of this devastating pandemic. COVID-19 represents the greatest threat to global public health and economies in the 21 st century.
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